Posted by admin On October 8, 2008
To protect against nuclease digestion, or single-strand binding protein interactions, oligonucleotides for targeted delivery into intracellular systems must be stable. To accomplish this, we have developed single-walled carbon nanotubes as a carrier for single-stranded DNA probe delivery. This has resulted in superior biostability for intracellular application and, hence, has achieved the desired protective attributes, which are particularly important when DNA probes are used for intracellular measurements. Specifically, when bound to single-walled carbon nanotubes, DNA probes are protected from enzymatic cleavage and interference from nucleic acid binding proteins. Read the rest of this entry »
Posted by admin On October 6, 2008
COLUMBIA, Mo. –According to the American Heart Association, three-fourths of people with diabetes die of some form of heart or blood-vessel disease. Previous studies have shown that cardiac function is compromised and cardiovascular diseases are increased in people with type 2 diabetes. Before vascular diseases develop in diabetics, blood-vessel cell dysfunction occurs. Using precise microscopes, University of Missouri researchers are dissecting coronary microvessels and testing which proteins are responsible for inflammation that causes blood-vessel dysfunction. By identifying the proteins that play important roles in blood-vessel dysfunction, they hope to develop new treatments for blood-vessel dysfunction in people with type 2 diabetes. Read the rest of this entry »
Posted by admin On October 6, 2008
A study led by researchers at the University of California, San Diego School of Medicine suggests that use of oral Vitamin D supplements bolsters production of a protective chemical normally found in the skin, and may help prevent skin infections that are a common result of atopic dermatitis, the most common form of eczema.
The study – led by Richard Gallo, M.D., Ph.D., professor of medicine and chief of the Division of Dermatology at the UCSD School of Medicine and the Dermatology section of the Veterans Affairs San Diego Healthcare System, and Tissa R. Hata, M.D., associate professor of medicine at UC San Diego – found that use of oral vitamin D appeared to correct a defect in the immune systems in patients with this skin disease. Their findings will be published in the October 3 edition of the Journal of Allergy & Clinical Immunology Read the rest of this entry »
Posted by admin On October 2, 2008
Bethesda, MD (Oct. 1, 2008) – Patients who undergo a complete negative colonoscopy have a reduced incidence of colorectal cancer, confirms a study published in Clinical Gastroenterology and Hepatology. However, in the proximal colon, the incidence reduction of colorectal cancer following complete negative colonoscopy differs in magnitude and timing. The reduction of colorectal cancer is observed in about half of the 14 follow-up years and for the most part occurs after just seven years of follow-up. Clinical Gastroenterology and Hepatology is the official journal of the American Gastroenterological Association (AGA) Institute.
“Our study raises a question about the effectiveness of colonoscopy in usual clinical practice,” said Linda Rabeneck, MD, MPH, of the University of Toronto and Institute for Clinical Evaluative Sciences in Toronto and lead author of the study. “Our findings suggest that the effectiveness of colonoscopy is reduced for cancers arising in the proximal colon. Whether this is due to colonoscopy quality, or whether it is due to tumor biology is the key issue that we need to address.”
Findings
The relative rate of colorectal cancer overall and the relative rate of distal (left-sided) colorectal cancer in the study group remained significantly lower than the control population. The relative rate of proximal (right-sided) colorectal cancer was significantly lower than the control population in half of the follow-up years, mainly after seven years of follow-up. Read the rest of this entry »
Posted by admin On October 2, 2008
The patients with mild symptoms were advised to take the drugs only after the symptoms appears in a day .Also patients which were more affected were asked to take drug regularly in morning till they get symptom free.But know opposing the daily research pattern of drug treatment that is in morning patients are advised to make their drug pattern according to frequency and severity of the symptoms .As a result the patients get relief from the symptoms more fast .
The cause of allergic rhinitis is over-respond of immune system to non-infectious particles such as plant pollens, molds, dust mites, and animal hair etc which causes sneezing and congestion with skin redness and swollen membranes in the nasal passages .
Source : EurekAlert ! via American Academy of Otolaryngology — Head and Neck Surgery.
Posted by admin On September 8, 2008
According to a study it has been found that common painkillers reduces the level of PSA of man . PSA(prostate-specific antigen) is a blood biomarker which is used by physicians to test whether a person is at risk of prostate cancer. The study showed that it is helpful in reducing the risk of prostate cancer but use of painkillers as a treatment of this is not prescribed till by the authors of the study . As addressed by the authors on Sept. 8 in the journal Cancer,
“We showed that men who regularly took certain medications like aspirin and other non-steroidal anti-inflammatory drugs, or NSAIDS, had a lower serum PSA level,” these lines are said by Eric A. Singer, M.D., M.A., a urology resident at the University of Rochester Medical Center. “But there’s not enough data to say that men who took the medications were less likely to get prostate cancer. This was a limited study, and we do not know how many of those men actually got prostate cancer.”
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Posted by admin On September 1, 2008
It has been observed that men are more prone to heart risk as compared to women . According to a new research led by University of Leicester sex hormones are responsible for it. According to Dr Maciej Tomaszewski, New Blood Lecturer in Cardiovascular Medicine in the Department of Cardiovascular Sciences at the University of Leicester this problem of males occur due to naturally occurring sex hormones .The research was done by studying at least 1000 men having age group about 19 years at Young Men Cardiovascular Association study .They studied the interaction of sex hormones with the major heart disease like blood pressure,cholesterol and weight .
Estradiol and Estrone, called together Estrogens increases the level of bad cholesterol (LDL-cholesterol) and decrease the level of good one(HDL-cholesterol) . According to a talk with Dr Tomaszewski he commented that :“We examined associations of circulating estrogens (estradiol and estrone) as well as androgens (testosterone and androstenedione) with major cardiovascular risk factors (lipids, blood pressure, body mass) in 933 young (median age – 19 years), apparently healthy men. Read the rest of this entry »
Posted by admin On August 18, 2008
According to a research published in Neuropsychiatric Disease and Treatment journal it has been found that cocoa compounds can increase the blood flow to brain .Researchers found that increased blood flow to brain can help in developing potential to beat dementia and stroke and can also effect the impact cognitive behavior .
The data is provided by studying participants in age group from 59 to 83. Harvard medical scientists found that the participants who drank the cocoa flavanols had an increase in brain blood flow of about 8% in one week which had increased to about 10% in the next week .
American scientists found that due to slow flow rate of blood to brain it causes structural damage and dementia .The scientists believe that maintaining the blood flow will lower down the risk of the disease .
Dr .Harold Schmitz, Ph.D., chief science officer at Mars said that this research added a new step which increases body of literature which connects regular cocoa flavanol consumption to blood flow and the health in old age people .The research is going on and in few days it will help the old people to stay fit and fine mentally .
Posted by admin On August 8, 2008
Researchers at University of Florida College of Pharmacy have discovered a compound from the sea coast of Key Largo that inhibits growth of cancer cells in laboratory tests.The research can help in producing more effective drug for the disease .
The compound named is largazole which is derived from cyanobacteria which grows on coral reefs .The researchers produced their study at International natural products scientific meeting in Athens, Greece.The chemical structure of molecule of compound and it’s ability to inhibit cancer were reported in February in Journal of the American Chemical Society and the laboratory synthesis and description of it’s working as an anti-cancer is described on july 2.
Dr .Hendrik Luesch, Ph.D., an assistant professor in UF’s department of medicinal chemistry and the study principal investigator said that it will be exciting when a natural chemical will overcome all the chemical drugs to treat cancer .“Largazole” the name is given due to it’s structural features and Florida location .The scientists were checking the depth of seas from about 1960s but many of them loose interest because it is a very expensive and time consuming process .
Their are many common medications such as cholesterol-reducing statins and pain relivers which are produced from the products found on earth but “Largazole” is first anti cancer medical product which is approved since today .Their are almost 14 marine compounds which are under research .We know that their is a bank of medicines to be discovered under the depth of seas said “Luesch ”.
Posted by admin On August 7, 2008
Scientists at University of Manchester have made a 3D structure of Mps-1 which is a protein that regulates the number of chromosomes during cell division and can be used to prepair more effective cancer therapies .
Mps-1 belongs to family of protein namedkinases.When the subset or enzymes in these families work abnormally it leads to an outcome like cancer .There are about 500 kinases out of which only 100 are known and we have developed a 3D structure of only few out of them .Knowing structure will help in synthesizing new kinase which will prevent us from disease for example “Glivec” a kinase inhibitor for treating Leukaemia in the UK in 2001.
Mps-1 is important because it controls the number of chromosomes which is vital cause of cancer .The structure is developed by Dr Patrick Eyers and his team, including Hong Kong-born PhD student Matthew Chu by usind a “super microscope ” which uses Diamond Light synchrotron .
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